Isaac's Ant Foundation was created in honor of Isaac Calley. He enjoyed contemplating the fundamental questions in life, saying at the age of eight, "Time is the greatest force in nature because, without time, nothing happens." Isaac crossed over at age sixteen due to a seizure resulting from a hypoxic brain injury caused by medical negligence at birth.

Isaac felt strongly about the individual's responsibility to make the world a better place, which compelled him to help other individuals with cognitive and physical disabilities. The more Isaac learned about ants, the more he wanted to teach others how incredible they were. Isaac's Ant Foundation continues Isaac's work in his name.